Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium

Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species parasites belonging to the family Trypansomatida. The present study investigated antitrypanosomal antileishmanial activity chalcones flavanones from Polygonum salicifolium, which grows in wetlands Iraq. phytochemical evaluation plant yielded two chalcones, 2′,4′-dimethoxy-6′-hydroxychalcone 2′,5′-dimethoxy-4′,6′-dihydroxychalcone, flavanones, 5,7-dimethoxyflavanone 5,8-dimethoxy-7-hydroxyflavanone. showed good while were inactive. EC50 values for against Trypanosoma brucei (0.5 μg/mL), T. congolense (2.5 Leishmania mexicana (5.2 μg/mL) indicated it was most active compounds. None compounds displayed any toxicity human cell line, even at 100 µg/mL, or cross-resistance with first line clinical trypanocides, such as diamidines melaminophenyl arsenicals. Taken together, our provides significant data relation P. salicifolium both vitro. Further future research is suggested order investigate mode action extracted parasites.